AB-452672-4 POINT-BY-POINT PULSED FIELD ABLATION USING A MULTIMODALITY GENERATOR: COMPARISON WITH RADIOFREQUENCY ABLATION IN REMAPPED CHRONIC SWINE HEARTS.

In recent years, Pulsed Field Ablation (PFA) has emerged as a novel non thermal energy source for ablation. To compare lesion durability and collateral damage between unipolar/biphasic PFA RF delivered through contact-force sensing catheter both in point-by-point fashion. A 4 arm pre-clinical study (n=12 swine) was designed with the multimodality generator TRUPULSE™ 2. nominal dose (12 pulses) Group 1 whereas high (24 used to evaluate safety arms served controls deployed (Group 3) or market available 4) generators. focally deliver PFA/RF at right superior pulmonary vein (RSPV), left atrial posterior wall (LAPW) Roof, mitral isthmus (MI), cavotricuspid Isthmus (CTI), RA (RAPW). Average contact force 12.7±3.7g. Animals were remapped immediate post 28 days All animals euthanized gross necropsy histology followed. Acute RSPV isolation achieved all (Figure 1). At days, remapping showed that maintained but one animal 1) showing an electrical gap confirmed on histology. RAPW, CTI, MI (with exception of 2 animals, 3), LAPW per well. Differently from RF, had essentially similar histopathologic effect benign mature scar tissue repair no necrosis nor inflammation applied lateral did elicit phrenic nerve response during ablation confirming ablations done nerve. However, remap, stimulated and, remained intact signs Representative samples selected downstream/upstream organs including brain, rete mirabile, heart, lungs, liver, esophagus, spleen, kidneys, which evidence thrombo-embolic events. swine models, durable PVI lesions acutely without any sign after remap study. On histology, evolved inflammation. Further studies are needed investigate long-term efficacy this catheter.